/*!
 * jQuery ClassyGradient
 * www.class.pm
 *
 * Written by Marius Stanciu - Sergiu <marius@class.pm>
 * Licensed under the MIT license www.class.pm/LICENSE-MIT
 * Version 1.1.0
 *
 */

(function($) {
    $.ClassyGradient = function(element, options) {
        var defaults = {
            gradient: '0% #02CDE8, 100% #000000',
            width: 300,
            height: 18,
            point: 8,
            orientation: 'vertical',
            target: null,
            onChange: function() {

            },
            onInit: function() {

            }
        };
        var $element = $(element), _container, _canvas, $pointsContainer, $pointsInfos, $pointsInfosContent, $pointColor, $pointPosition, $btnPointDelete, _context, _selPoint;
        var points = new Array();
        this.settings = {};
        this.__constructor = function() {
            this.settings = $.extend({}, defaults, options);
            this.update();
            this.settings.onInit();
            return this;
        };
        this.update = function() {
            this._setupPoints();
            this._setup();
            this._render();
        };
        this.getCSS = function() {
            var out = '', svgX = '0%', svgY = '100%', webkitDir = 'left bottom', defDir = 'top';
            if (this.settings.orientation === 'horizontal') {
                svgX = '100%';
                svgY = '0%';
                webkitDir = 'right top';
                defDir = 'left';
            }

			defDir = this.settings.orientation; // hack by amit

            var svg = '<svg xmlns="http://www.w3.org/2000/svg">' + '<defs>' + '<linearGradient id="gradient" x1="0%" y1="0%" x2="' + svgX + '" y2="' + svgY + '">';
            var webkitCss = '-webkit-gradient(linear, left top, ' + webkitDir;
            var defCss = '';
            $.each(points, function(i, el) {
                webkitCss += ', color-stop(' + el[0] + ', ' + el[1] + ')';
                defCss += ',' + el[1] + ' ' + el[0] + '';
                svg += '<stop offset="' + el[0] + '" style="stop-color:' + el[1] + ';" />';
            });
            webkitCss += ')';
            defCss = defCss.substr(1);
            svg += '</linearGradient>' + '</defs>' + '<rect fill="url(#gradient)" height="100%" width="100%" />' + '</svg>';
            svg = this._base64(svg);
            out += 'background: url(data:image/svg+xml;base64,' + svg + ');' + '\n';
            out += 'background: ' + webkitCss + ';\n';
            out += 'background: ' + '-moz-linear-gradient(' + defDir + ',' + defCss + ');' + '\n';
            out += 'background: ' + '-webkit-linear-gradient(' + defDir + ',' + defCss + ');' + '\n';
            out += 'background: ' + '-o-linear-gradient(' + defDir + ',' + defCss + ');' + '\n';
            out += 'background: ' + '-ms-linear-gradient(' + defDir + ',' + defCss + ');' + '\n';
            out += 'background: ' + 'linear-gradient(' + defDir + ',' + defCss + ');';
            return out;
        };
        this.getArray = function() {
            return points;
        };
        this.getString = function() {
            var out = '';
            $.each(points, function(i, el) {
                out += el[0] + ' ' + el[1] + ',';
            });
            out = out.substr(0, out.length - 1);
            return out;
        };
        this.setOrientation = function(orientation) {
            this.settings.orientation = orientation;
            this._renderToTarget();
        };
        this._setupPoints = function() {
            points = new Array();
            if ($.isArray(this.settings.gradient)) {
                points = this.settings.gradient;
            }
            else {
                points = this._getGradientFromString(this.settings.gradient);
            }
        };
        this._setup = function() {
            var self = this;
            $element.empty();
            _container = $('<div class="ClassyGradient"></div>');
            _canvas = $('<canvas class="canvas" width="' + this.settings.width + '" height="' + this.settings.height + '"></canvas>');
            _container.append(_canvas);
            _context = _canvas.get(0).getContext('2d');
            $pointsContainer = $('<div class="points"></div>');
            $pointsContainer.css('width', (this.settings.width) + Math.round(this.settings.point / 2 + 1) + 'px');
            _container.append($pointsContainer);
            $pointsInfos = $('<div class="info"></div>');
            $pointsInfos.append('<div class="arrow"></div>');
            _container.append($pointsInfos);
            $pointsInfosContent = $('<div class="content"></div>');
            $pointsInfos.append($pointsInfosContent);
            $element.hover(function() {
                $element.addClass('hover');
            }, function() {
                $element.removeClass('hover');
            });
            $pointColor = $('<div class="point-color"><div style="background-color: #00ff00"></div></div>');
            $pointPosition = $('<span class="point-position">%</span>');
            $btnPointDelete = $('<a href="#" class="delete"></a>');
            $pointsInfosContent.append($pointColor, $pointPosition, $btnPointDelete);
            $element.append(_container);
            $pointColor.ColorPicker({
                color: '#00ff00',
                onSubmit: function(hsb, hex, rgb) {
                    $element.find('.point-color div').css('backgroundColor', '#' + hex);
                    _selPoint.css('backgroundColor', '#' + hex);
                    self._renderCanvas();
                    self._renderToTarget();
                },
                onChange: function(hsb, hex, rgb) {
                    $element.find('.point-color div').css('backgroundColor', '#' + hex);
                    _selPoint.css('backgroundColor', '#' + hex);
                    self._renderCanvas();
                    self._renderToTarget();
                }
            });
            $(document).bind('click', function() {
                if (!$element.is('.hover')) {
                    $pointsInfos.hide('fast');
                }
            });
            _canvas.unbind('click');
            _canvas.bind('click', function(e) {
                var offset = _canvas.offset(), clickPosition = e.pageX - offset.left;
                clickPosition = Math.round((clickPosition * 100) / self.settings.width);
                var defaultColor = '#000000', minDist = 999999999999;
                $.each(points, function(i, el) {
                    if ((parseInt(el[0]) < clickPosition) && (clickPosition - parseInt(el[0]) < minDist)) {
                        minDist = clickPosition - parseInt(el[0]);
                        defaultColor = el[1];
                    }
                    else if ((parseInt(el[0]) > clickPosition) && (parseInt(el[0]) - clickPosition < minDist)) {
                        minDist = parseInt(el[0]) - clickPosition;
                        defaultColor = el[1];
                    }
                });
                points.push([clickPosition + '%', defaultColor]);
                points.sort(self._sortByPosition);
                self._render();
                $.each(points, function(i, el) {
                    if (el[0] == clickPosition + '%') {
                        self._selectPoint($pointsContainer.find('.point:eq(' + i + ')'));
                    }
                });
            });
        };
        this._render = function() {
            this._initGradientPoints();
            this._renderCanvas();
            this._renderToTarget();
        };
        this._initGradientPoints = function() {
            var self = this;
            $pointsContainer.empty();
            $.each(points, function(i, el) {
                $pointsContainer.append('<div class="point" style="background-color: ' + el[1] + '; left:' + (parseInt(el[0]) * self.settings.width) / 100 + 'px;"></div>');
            });
            $pointsContainer.find('.point').css('width', this.settings.point + 'px').css('height', this.settings.point + 'px').mouseup(function() {
                self._selectPoint(this);
            }).draggable({
                axis: 'x',
                containment: 'parent',
                drag: function() {
                    self._selectPoint(this);
                    self._renderCanvas();
                    self._renderToTarget();
                }
            });
        };
        this._selectPoint = function(el) {
            var self = this;
            _selPoint = $(el);
            var color = $(el).css('backgroundColor'), position = parseInt($(el).css('left'));
            position = Math.round((position / this.settings.width) * 100);
            color = color.substr(4, color.length);
            color = color.substr(0, color.length - 1);
            $pointColor.ColorPickerSetColor(this._rgbToHex(color.split(',')));
            $pointColor.find('div').css('backgroundColor', this._rgbToHex(color.split(',')));
            $pointPosition.html('Position: ' + position + '%');
            $btnPointDelete.unbind('click').bind('click', function() {
                if (points.length > 1) {
                    points.splice(_selPoint.index(), 1);
                    self._render();
                    $element.find('.info').hide('fast');
                }
                return false;
            });
            $element.find('.info').css('marginLeft', parseInt($(el).css('left')) - 30 + 'px').show('fast');
        };
        this._renderCanvas = function() {
            var self = this;
            points = new Array();
            $element.find('.point').each(function(i, el) {
                var position = Math.round((parseInt($(el).css('left')) / self.settings.width) * 100);
                var color = $(el).css('backgroundColor').substr(4, $(el).css('backgroundColor').length - 5);
                color = self._rgbToHex(color.split(','));
                points.push([position + '%', color]);
            });
            points.sort(self._sortByPosition);
            this._renderToCanvas();
            this.settings.onChange(this.getString(), this.getCSS(), this.getArray());
        };
        this._renderToElement = function(target, gradient) {
            var svgX = '0%', svgY = '100%', webkitDir = 'left bottom', defDir = 'top';
            if ((target === _canvas) || (this.settings.orientation === 'horizontal')) {
                svgX = '100%';
                svgY = '0%';
                webkitDir = 'right top';
                defDir = 'left';
            }
			
			defDir = this.settings.orientation; // hack by amit
            
			var svg = '<svg xmlns="http://www.w3.org/2000/svg">' + '<defs>' + '<linearGradient id="gradient" x1="0%" y1="0%" x2="' + svgX + '" y2="' + svgY + '">';
            var webkitCss = '-webkit-gradient(linear, left top, ' + webkitDir;
            var defCss = '';
            $.each(gradient, function(i, el) {
                webkitCss += ', color-stop(' + el[0] + ', ' + el[1] + ')';
                defCss += ',' + el[1] + ' ' + el[0] + '';
                svg += '<stop offset="' + el[0] + '" style="stop-color:' + el[1] + ';" />';
            });
            webkitCss += ')';
            defCss = defCss.substr(1);
            svg += '</linearGradient>' + '</defs>';
            if (target === $pointsInfosContent) {
                var tooltipRadius = parseInt($pointsInfosContent.css('borderRadius'));
                svg += '<rect fill="url(#gradient)" height="100%" width="100%" rx="' + tooltipRadius + '" ry="' + tooltipRadius + '" />';
            }
            else {
                svg += '<rect fill="url(#gradient)" height="100%" width="100%" />';
            }
            svg += '</svg>';
            svg = this._base64(svg);
            target.css('background', 'url(data:image/svg+xml;base64,' + svg + ')');
            target.css('background', webkitCss);
            target.css('background', '-moz-linear-gradient(' + defDir + ',' + defCss + ')');
            target.css('background', '-webkit-linear-gradient(' + defDir + ',' + defCss + ')');
            target.css('background', '-o-linear-gradient(' + defDir + ',' + defCss + ')');
            target.css('background', '-ms-linear-gradient(' + defDir + ',' + defCss + ')');
            target.css('background', 'linear-gradient(' + defDir + ',' + defCss + ')');
        };
        this._renderToTarget = function() {
            if (this.settings.target !== null) {
                this._renderToElement($(this.settings.target), points);
            }
        };
        this._renderToCanvas = function() {
            var gradient = _context.createLinearGradient(0, 0, this.settings.width, 0);
            $.each(points, function(i, el) {
                gradient.addColorStop(parseInt(el[0]) / 100, el[1]);
            });
            _context.clearRect(0, 0, this.settings.width, this.settings.height);
            _context.fillStyle = gradient;
            _context.fillRect(0, 0, this.settings.width, this.settings.height);
            this.settings.onChange(this.getString(), this.getCSS(), this.getArray());
        };
        this._getGradientFromString = function(gradient) {
            var arr = new Array(), _t = gradient.split(',');
            $.each(_t, function(i, el) {
                var position;
                if ((el.substr(el.indexOf('%') - 3, el.indexOf('%')) == '100') || (el.substr(el.indexOf('%') - 3, el.indexOf('%')) == '100%')) {
                    position = '100%';
                }
                else if (el.indexOf('%') > 1) {
                    position = parseInt(el.substr(el.indexOf('%') - 2, el.indexOf('%')));
                    position += '%';
                }
                else {
                    position = parseInt(el.substr(el.indexOf('%') - 1, el.indexOf('%')));
                    position += '%';
                }
                var color = el.substr(el.indexOf('#'), 7);
                arr.push([position, color]);
            });
            return arr;
        };
        this._rgbToHex = function(rgb) {
            var R = rgb[0], G = rgb[1], B = rgb[2];
            function toHex(n) {
                n = parseInt(n, 10);
                if (isNaN(n))
                    return "00";
                n = Math.max(0, Math.min(n, 255));
                return "0123456789ABCDEF".charAt((n - n % 16) / 16) + "0123456789ABCDEF".charAt(n % 16);
            }
            return '#' + toHex(R) + toHex(G) + toHex(B);
        };
        this._sortByPosition = function(data_A, data_B) {
            if (parseInt(data_A[0]) < parseInt(data_B[0])) {
                return -1;
            }
            if (parseInt(data_A[0]) > parseInt(data_B[0])) {
                return 1;
            }
            return 0;
        };
        this._base64 = function(input) {
            var keyStr = "ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=", output = "", chr1, chr2, chr3, enc1, enc2, enc3, enc4, i = 0;
            while (i < input.length) {
                chr1 = input.charCodeAt(i++);
                chr2 = input.charCodeAt(i++);
                chr3 = input.charCodeAt(i++);
                enc1 = chr1 >> 2;
                enc2 = ((chr1 & 3) << 4) | (chr2 >> 4);
                enc3 = ((chr2 & 15) << 2) | (chr3 >> 6);
                enc4 = chr3 & 63;
                if (isNaN(chr2)) {
                    enc3 = enc4 = 64;
                }
                else if (isNaN(chr3)) {
                    enc4 = 64;
                }
                output += keyStr.charAt(enc1) + keyStr.charAt(enc2) + keyStr.charAt(enc3) + keyStr.charAt(enc4);
            }
            return output;
        };
        return this.__constructor();
    };
    $.fn.ClassyGradient = function(options) {
        return this.each(function() {
            if ($(this).data('ClassyGradient') === undefined) {
                var plugin = new $.ClassyGradient(this, options);
                $(this).data('ClassyGradient', plugin);
            }
        });
    };
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	<h2 class="single-post-title entry-title" itemprop="headline">Tamoxifen Dosage: A Comprehensive Guide</h2><!-- .single-post-title -->
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					<li class="meta-author" itemprop="name"><span class="screen-reader-text">Auteur/autrice de la publication :</span><i class=" icon-user" aria-hidden="true" role="img"></i><a href="https://maboitabb.com/author/bbd2f7ac/" title="Articles par bbd2f7ac" rel="author"  itemprop="author" itemscope="itemscope" itemtype="https://schema.org/Person">bbd2f7ac</a></li>
		
		
		
		
		
		
	
		
					<li class="meta-date" itemprop="datePublished"><span class="screen-reader-text">Publication publiée :</span><i class=" icon-clock" aria-hidden="true" role="img"></i>5 août 2024</li>
		
		
		
		
		
	
		
		
		
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	<h1>Tamoxifen Dosage: A Comprehensive Guide</h1>
<p>Tamoxifen is a widely used medication in the treatment of breast cancer, particularly in hormone receptor-positive cases. Understanding the appropriate <strong>tamoxifen dosage</strong> is crucial for maximizing its effectiveness while minimizing side effects.</p>
<h2>Understanding Tamoxifen</h2>
<p>Tamoxifen works by blocking estrogen receptors in breast tissue, thereby inhibiting the growth of estrogen-dependent tumors. It is often prescribed for both premenopausal and postmenopausal women as part of a comprehensive treatment plan.</p>
<h3>Standard Dosage Guidelines</h3>
<p>The standard <strong>tamoxifen dosage</strong> for adults is typically 20 mg per day. This dosage may be administered as a single dose or divided into two smaller doses throughout the day. In some cases, physicians may adjust the dosage based on individual patient needs and responses.</p>
<h3>Factors Influencing Dosage</h3>
<p>Several factors can influence the recommended tamoxifen dosage, including:</p>
<ul>
<li><strong>Age:</strong> Older patients may metabolize drugs differently.</li>
<li><strong>Weight:</strong> Body mass can affect drug distribution and elimination.</li>
<li><strong>Kidney and Liver Function:</strong> Impaired organ function may necessitate dosage adjustments.</li>
<li><strong>Concurrent Medications:</strong> Certain medications can interact with tamoxifen, altering its effectiveness and required dosage.</li>
</ul>
<h2>Duration of Treatment</h2>
<p>The duration of tamoxifen therapy usually spans five to ten years, particularly in patients at high risk of recurrence. Continuous evaluation by healthcare providers is essential to determine the optimal length of treatment based on individual circumstances.</p>
<h3>Monitoring and Side Effects</h3>
<p>Patients on <strong>tamoxifen</strong> should be regularly <a href="https://tamoxifenbuy.com/">tamoxifen order online</a> monitored for potential side effects, which may include:</p>
<ul>
<li>Hot flashes</li>
<li>Nausea</li>
<li>Fatigue</li>
<li>Risk of blood clots</li>
</ul>
<p>It is vital to communicate any adverse reactions to healthcare providers promptly to manage them effectively.</p>
<h2>Conclusion</h2>
<p>Determining the right tamoxifen dosage is a critical aspect of breast cancer treatment. By adhering to medical advice and maintaining open communication with healthcare providers, patients can optimize their treatment outcomes and mitigate risks associated with this important medication.</p>

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<p>Régulièrement interrogée par de futures ou jeunes reborneuses qui se posent mille et une questions, j’ai décidé de créer ce petit magazine.<br />
J’aurais aimé pouvoir disposer de ce genre de support lorsque j’ai débuté dans cette activité d&rsquo;artisanat d&rsquo;art.<br />
Alors je sais qu’il peut être utile.<br />
Il s&rsquo;appelle Bébés Reborn Mag et c&rsquo;est LE magazine de la Reborneuse.<br />
J’y partage mon expérience de plus de 120 bébés reborn créés à ce jour, mes ressentis, mes analyses.</p>
<p>Les contenus n&rsquo;engagent que moi et n&rsquo;attendent pas l&rsquo;adhésion de l&rsquo;ensemble des reborneuses, cette activité restant artistique pour une part, et par conséquent personnelle.</p>
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